Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cdh2  cadherin 2   (Synonyms: Ncad, N-CAD, N-cadherin)
Results	Reference
1	J:330973 Brault JB, Bardin S, Lampic M, Carpentieri JA, Coquand L, Penisson M, Lachuer H, Victoria GS, Baloul S, El Marjou F, Boncompain G, Miserey-Lenkei S, Belvindrah R, Fraisier V, Francis F, Perez F, Goud B, Baffet AD, RAB6 and dynein drive post-Golgi apical transport to prevent neuronal progenitor delamination. EMBO Rep. 2022 Oct 6;23(10):e54605
1	J:302526 Cao X, An J, Cao Y, Lv J, Wang J, Ding Y, Lin X, Zhou X, EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development. Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):31
1	J:194489 Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX, The wilms tumor gene, wt1, maintains testicular cord integrity by regulating the expression of col4a1 and col4a2. Biol Reprod. 2013;88(3):56
1	J:184469 Cho SH, Kim JY, Simons DL, Song JY, Le JH, Swindell EC, Jamrich M, Wu SM, Kim S, Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis. Hum Mol Genet. 2012 Jun 15;21(12):2663-76
1	J:74658 Dahl U, Sjodin A, Larue L, Radice GL, Cajander S, Takeichi M, Kemler R, Semb H, Genetic dissection of cadherin function during nephrogenesis. Mol Cell Biol. 2002 Mar;22(5):1474-87
1*	J:273130 Ding W, Wu Q, Sun L, Pan NC, Wang X, Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex. J Neurosci. 2019 Mar 13;39(11):1994-2010
1*	J:84816 Fagman H, Grande M, Edsbagge J, Semb H, Nilsson M, Expression of classical cadherins in thyroid development: maintenance of an epithelial phenotype throughout organogenesis. Endocrinology. 2003 Aug;144(8):3618-24
1	J:256059 Falk S, Bugeon S, Ninkovic J, Pilz GA, Postiglione MP, Cremer H, Knoblich JA, Gotz M, Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding. Neuron. 2017 Feb 22;93(4):777-791.e3
1*	J:327413 Gillnas S, Gallini R, He L, Betsholtz C, Andrae J, Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRalpha signalling in cerebellar development. Biol Open. 2022 Aug 15;11(8):bio059431
1	J:180109 Guntur AR, Rosen CJ, Naski MC, N-cadherin adherens junctions mediate osteogenesis through PI3K signaling. Bone. 2012 Jan;50(1):54-62
1	J:238096 Houlihan SL, Lanctot AA, Guo Y, Feng Y, Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis. Elife. 2016 Sep 24;5:e17823
1	J:294837 Huang C, Liu T, Wang Q, Hou W, Zhou C, Song Z, Shi YS, Gao X, Chen G, Yin Z, Hu Y, Loss of PP2A Disrupts the Retention of Radial Glial Progenitors in the Telencephalic Niche to Impair the Generation for Late-Born Neurons During Cortical Development. Cereb Cortex. 2020 Jun 1;30(7):4183-4196
1	J:122204 Imai F, Hirai S, Akimoto K, Koyama H, Miyata T, Ogawa M, Noguchi S, Sasaoka T, Noda T, Ohno S, Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development. 2006 May;133(9):1735-44
1*	J:215665 Insolera R, Shao W, Airik R, Hildebrandt F, Shi SH, SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing cortex. Neuron. 2014 Aug 20;83(4):805-22
1	J:163480 Johansson JK, Voss U, Kesavan G, Kostetskii I, Wierup N, Radice GL, Semb H, N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover. Genesis. 2010 Jun;48(6):374-81
1	J:312468 Jorgensen R, Katta M, Wolfe J, Leach DF, Lavelle B, Chun J, Wilsbacher LD, Deletion of Sphingosine 1-Phosphate receptor 1 in cardiomyocytes during development leads to abnormal ventricular conduction and fibrosis. Physiol Rep. 2021 Oct;9(19):e15060
1	J:134436 Kadowaki M, Nakamura S, Machon O, Krauss S, Radice GL, Takeichi M, N-cadherin mediates cortical organization in the mouse brain. Dev Biol. 2007 Apr 1;304(1):22-33
1*	J:332214 Kaiser M, Ludtke TH, Deuper L, Rudat C, Christoffels VM, Kispert A, Trowe MO, TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti. Nat Commun. 2022 Dec 9;13(1):7628
1	J:117056 Kan NG, Stemmler MP, Junghans D, Kanzler B, de Vries WN, Dominis M, Kemler R, Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development. 2007 Jan;134(1):31-41
1	J:155751 Kang W, Wong LC, Shi SH, Hebert JM, The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis. J Neurosci. 2009 Nov 18;29(46):14571-80
1	J:102364 Koike C, Nishida A, Akimoto K, Nakaya MA, Noda T, Ohno S, Furukawa T, Function of atypical protein kinase Clambda in differentiating photoreceptors is required for proper lamination of mouse retina. J Neurosci. 2005 Nov 2;25(44):10290-8
1	J:138572 Komada M, Saitsu H, Kinboshi M, Miura T, Shiota K, Ishibashi M, Hedgehog signaling is involved in development of the neocortex. Development. 2008 Aug;135(16):2717-27
1	J:219376 La Fata G, Gartner A, Dominguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, Bagni C, FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry. Nat Neurosci. 2014 Dec;17(12):1693-700
1	J:181885 Liu C, Bakeri H, Li T, Swaroop A, Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma. Hum Mol Genet. 2012 Apr 15;21(8):1848-60
1*	J:226036 Maddala R, Nagendran T, Lang RA, Morozov A, Rao PV, Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. Dev Biol. 2015 Oct 1;406(1):74-91
1	J:240358 Maeta K, Edamatsu H, Nishihara K, Ikutomo J, Bilasy SE, Kataoka T, Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex. eNeuro. 2016 May-Jun;3(3):ENEURO.0142-16.2016
1	J:220152 Marcos S, Nieto-Lopez F, Sandonis A, Cardozo MJ, Di Marco F, Esteve P, Bovolenta P, Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms. J Neurosci. 2015 Mar 18;35(11):4729-40
1	J:304719 Morcom L, Gobius I, Marsh AP, Suarez R, Lim JW, Bridges C, Ye Y, Fenlon LR, Zagar Y, Douglass AM, Donahoo AL, Fothergill T, Shaikh S, Kozulin P, Edwards TJ, Cooper HM, Sherr EH, Chedotal A, Leventer RJ, Lockhart PJ, Richards LJ, DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. Elife. 2021 Apr 19;10:e61769
1	J:124940 Nechiporuk T, Fernandez TE, Vasioukhin V, Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in dlg5(-/-) mice. Dev Cell. 2007 Sep;13(3):338-50
1*	J:41888 Packer AI, Elwell VA, Parnass JD, Knudsen KA, Wolgemuth DJ, N-cadherin protein distribution in normal embryos and in embryos carrying mutations in the homeobox gene Hoxa-4. Int J Dev Biol. 1997 Jun;41(3):459-68
1	J:240000 Park JY, Hughes LJ, Moon UY, Park R, Kim SB, Tran K, Lee JS, Cho SH, Kim S, The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. Development. 2016 Jan 01;143(1):133-46
1	J:131815 Pontoriero GF, Deschamps P, Ashery-Padan R, Wong R, Yang Y, Zavadil J, Cvekl A, Sullivan S, Williams T, West-Mays JA, Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype. Dev Dyn. 2008 Mar;237(3):602-17
1	J:161883 Sasse P, Malan D, Fleischmann M, Roell W, Gustafsson E, Bostani T, Fan Y, Kolbe T, Breitbach M, Addicks K, Welz A, Brem G, Hescheler J, Aszodi A, Costell M, Bloch W, Fleischmann BK, Perlecan is critical for heart stability. Cardiovasc Res. 2008 Dec 1;80(3):435-44
1	J:181974 Seo S, Singh HP, Lacal PM, Sasman A, Fatima A, Liu T, Schultz KM, Losordo DW, Lehmann OJ, Kume T, Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
1	J:346597 Seo S, Sonn SK, Kweon HY, Jin J, Kume T, Ko JY, Park JH, Oh GT, Primary Cilium in Neural Crest Cells Crucial for Anterior Segment Development and Corneal Avascularity. Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):30
1	J:293277 Shao W, Yang J, He M, Yu XY, Lee CH, Yang Z, Joyner AL, Anderson KV, Zhang J, Tsou MB, Shi H, Shi SH, Centrosome anchoring regulates progenitor properties and cortical formation. Nature. 2020 Apr;580(7801):106-112
1	J:213479 Shibasaki T, Tokunaga A, Sakamoto R, Sagara H, Noguchi S, Sasaoka T, Yoshida N, PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus. Cereb Cortex. 2013 Aug;23(8):1824-35
1	J:312425 Shukla S, Haenold R, Urbanek P, Frappart L, Monajembashi S, Grigaravicius P, Nagel S, Min WK, Tapias A, Kassel O, Heuer H, Wang ZQ, Ploubidou A, Herrlich P, TRIP6 functions in brain ciliogenesis. Nat Commun. 2021 Oct 7;12(1):5887
1	J:137035 Solberg N, Machon O, Krauss S, Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool. Dev Dyn. 2008 Jul;237(7):1799-811
1	J:278287 Tang T, Zhang Y, Wang Y, Cai Z, Lu Z, Li L, Huang R, Hagelkruys A, Matthias P, Zhang H, Seiser C, Xie Y, HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development. Neuron. 2019 Mar 20;101(6):1117-1133.e5
1	J:270077 Tapias A, Zhou ZW, Shi Y, Chong Z, Wang P, Groth M, Platzer M, Huttner W, Herceg Z, Yang YG, Wang ZQ, Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions. Cell Stem Cell. 2014 May 1;14(5):632-43
1	J:237527 Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, Blackshaw S, Control of lens development by Lhx2-regulated neuroretinal FGFs. Development. 2016 Nov 01;143(21):3994-4002
1	J:190680 Toyama H, Arai F, Hosokawa K, Ikushima YM, Suda T, N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs. Biochem Biophys Res Commun. 2012 Nov 23;428(3):354-9
1	J:152174 Weimer JM, Yokota Y, Stanco A, Stumpo DJ, Blackshear PJ, Anton ES, MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex. Development. 2009 Sep;136(17):2965-75
1	J:283329 Zhang T, Hou C, Zhang S, Liu S, Li Z, Gao J, Lgl1 deficiency disrupts hippocampal development and impairs cognitive performance in mice. Genes Brain Behav. 2019 Nov;18(8):e12605